4-Coumaric acid → HCID 131735719, compound

HRID 2201598Notes

Reaction equation

HRID 2201598 reaction equation
[OH:1][C:2]1[CH:13]=[CH:12][C:5]([CH:6]=[CH:7][C:8]([CH2:10]I)=[O:9])=[CH:4][CH:3]=1.[Na].[K].[OH:16][C:17]1[CH:27]=[CH:26][C:20]([CH:21]=[CH:22][C:23]([OH:25])=[O:24])=[CH:19][CH:18]=1>>[OH:16][C:17]1[CH:18]=[CH:19][C:20]([CH:21]=[CH:22][C:23]([O:25][CH2:10][C:8](=[O:9])[CH:7]=[CH:6][C:5]2[CH:12]=[CH:13][C:2]([OH:1])=[CH:3][CH:4]=2)=[O:24])=[CH:26][CH:27]=1

Participants

5

Reactant 4

HCID 3224-Coumaric acidHCID 5360545SodiumHCID 5462222PotassiumHCID 131735720HCID 131735720, compound

Product 1

HCID 131735719HCID 131735719, compound

Procedure

Bis-demethoxycalebin-A (4-Hydroxycinnamoylmethyl 4-hydroxycinnamate, 10d) was prepared by reacting 4-hydroxycinnamoyliodomethane with sodium or potassium salt of 4-hydroxycinnamic acid with reaction steps and conditions maintained as mentioned in the general synthetic scheme discussed herein above in Para 0010. The yield of the product was 55%.

Workup

  1. customwith reaction steps and conditions
  2. temperaturemaintained

Sources & evidence

ORD record
ord-b5a9c9cfbd8a40da886d41e324e4b890
Source dataset
uspto-grants-2016_06
Patent number
US09365486B2

Reaction notes

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