反应详情

Hydrazine hydrate (5 mL) was added to a solution of Example 93C (1.07 g, 2.96 mmol) in dioxane (10 mL). The resulting solution was refluxed for 3 hours before it was cooled and partitioned with tetrahydrofuran and brine. The aqueous phase was acidified with 6 N hydrochloric acid to pH 2 and extracted repeatedly with a tetrahydrofuran/ethyl acetate mixture. The combined organic phases were dried (magnesium sulfate), filtered, and concentrated. The crude product was recrystallized from ethyl acetate and hexane to provide a light brown solid.

1. temperatureThe resulting solution was refluxed for 3 hours before it
2. temperaturewas cooled
3. custompartitioned with tetrahydrofuran and brine
4. extractionextracted repeatedly with a tetrahydrofuran/ethyl acetate mixture
5. dry with materialThe combined organic phases were dried (magnesium sulfate)
6. filtrationfiltered
7. concentrationconcentrated
8. customThe crude product was recrystallized from ethyl acetate and hexane
9. customto provide a light brown solid