Dimethylamine → HCID 13355362, compound

HRID 2201614Notes

Reaction equation

HRID 2201614 reaction equation
[Br:1][C:2]([F:9])([F:8])[C:3](OCC)=[O:4].[NH:10]([CH3:12])[CH3:11]>C1COCC1>[Br:1][C:2]([F:9])([F:8])[C:3]([N:10]([CH3:12])[CH3:11])=[O:4]

Participants

4

Reactant 2

HCID 674DimethylamineHCID 69585Ethyl bromodifluoroacetate

Product 1

HCID 13355362HCID 13355362, compoundYield 93%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

To a solution of ethyl bromodifluoroacetate (370 g, 1.82 mol) in 1000 mL of THF was added a solution of Me2NH in THF (2.0 M, 1000 mL, 2.0 mol). A slightly exothermic reaction occurred. The solution was stirred at room temperature overnight. The solvent was then carefully removed by distillation and the residue purified by rectification. The product was obtained as a colorless liquid (343 g, >99% pure by GC, 1.7 mol, 93% yield).

Workup

  1. customA slightly exothermic reaction
  2. customThe solvent was then carefully removed by distillation
  3. customthe residue purified by rectification
  4. customThe product was obtained as a colorless liquid (343 g, >99% pure by GC, 1.7 mol, 93% yield)

Sources & evidence

ORD record
ord-7da5c28306474ce0a1bf7fdc13643c19
Source dataset
uspto-grants-2016_06
Patent number
US09365495B2

Reaction notes

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