Pyrrolidine → HCID 69671577, compound

HRID 2201616Notes

Reaction equation

[NH:1]1[CH2:5][CH2:4][CH2:3][CH2:2]1.[Br:6][C:7]([F:14])([F:13])[C:8](OCC)=[O:9]>>[Br:6][C:7]([F:14])([F:13])[C:8]([N:1]1[CH2:5][CH2:4][CH2:3][CH2:2]1)=[O:9]

Participants

Reactant 2

HCID 31268Pyrrolidine

HCID 69585Ethyl bromodifluoroacetate

Product 1

HCID 69671577HCID 69671577, compound

Procedure

Pyrrolidine (7.7 g, 108 mmol) was added to ethyl bromodifluoroacetate (20.2 g, 100 mmol) at 30° C. The mixture was stirred for 60 min; then all volatiles were removed under reduced pressure and the residue (24.0 g, >90% purity by NMR) was used in subsequent steps without further purification.

Workup

customthen all volatiles were removed under reduced pressure
customthe residue (24.0 g, >90% purity by NMR) was used in subsequent steps without further purification

Sources & evidence

ORD record: ord-2a324601e551416d842782b20df8fb8c
Source dataset: uspto-grants-2016_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09365495B2

Reaction notes

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