Trifluoroacetic acid → HCID 86723562, compound

HRID 2201656Notes

Reaction equation

HRID 2201656 reaction equation
[CH2:1]1[C:3]2([CH2:6][CH:5]([NH:7]C(=O)OC(C)(C)C)[CH2:4]2)[CH2:2]1.[F:15][C:16]([F:21])([F:20])[C:17]([OH:19])=[O:18]>>[F:15][C:16]([F:21])([F:20])[C:17]([OH:19])=[O:18].[CH2:2]1[C:3]2([CH2:6][CH:5]([NH2:7])[CH2:4]2)[CH2:1]1

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86723561HCID 86723561, compound

Product 1

HCID 86723562HCID 86723562, compound

Procedure

The above obtained Compound 3-3 (1 g, 5.1 mmol) was dissolved in 5 mL of trifluoroacetic acid, stirred for 10 minutes, rotary evaporated to remove trifluoroacetic acid to give 1.1 g of Compound 3-4 and used directly in the next step reactions.

Workup

  1. customrotary evaporated
  2. customto remove trifluoroacetic acid

Sources & evidence

ORD record
ord-1ad004ff9147431598a2efb02fb9d629
Source dataset
uspto-grants-2016_06
Patent number
US09365499B2

Reaction notes

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