反应详情

2-(4-Bromo-phenyl)-4-(tert-butyl-dimethyl-silanyloxy)-butyric acid ethyl ester (XXXI) is prepared by alkylation of the corresponding potassium enolate with XXX. The reaction is typically carried out by deprotonating (4-bromo-phenyl)-acetic acid ethyl ester with potassium tert-butoxide in dimethylformamide at room temperature for one hour, then cooling the reaction to zero degrees Celsius and slowly adding XXX, followed by stirring at room temperature for twelve hours.

1. customat room temperature
2. customfor one hour
3. temperaturecooling
4. customthe reaction to zero degrees Celsius