Trifluoroacetic acid → HCID 86723564, compound

HRID 2201662Notes

Reaction equation

HRID 2201662 reaction equation
[CH2:1]1[C:3]2([CH2:8][CH2:7][CH:6]([NH:9]C(=O)OC(C)(C)C)[CH2:5][CH2:4]2)[CH2:2]1.[C:17]([OH:23])([C:19]([F:22])([F:21])[F:20])=[O:18]>C(Cl)Cl>[F:20][C:19]([F:22])([F:21])[C:17]([OH:23])=[O:18].[CH2:2]1[C:3]2([CH2:8][CH2:7][CH:6]([NH2:9])[CH2:5][CH2:4]2)[CH2:1]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 59578632HCID 59578632, compound

Product 1

HCID 86723564HCID 86723564, compoundYield 99.8%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Compound 7-3 (1.5 g, 6.7 mmol) was dissolved in 15 mL of DCM and TFA (2.5 mL) was added and stirred for 1 hour to give Compound 7-4 (1.6 g, 99.8% yield).

Sources & evidence

ORD record
ord-618ce11853ac4918bced61507e19949b
Source dataset
uspto-grants-2016_06
Patent number
US09365499B2

Reaction notes

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