HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → {spiro[2.5]octan-6-yl}methanamine hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | HCID 71243330 | HCID 71243330 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | {spiro[2.5]octan-6-yl}methanamine hydrochloride | HCID 68704587 | 98.5% |
Reaction Steps
Compound 8-5 (2.85 g, 10.4 mmol) was dissolved in 30 mL of methanol, added 0.2 g of palladium on carbon and 1 mL of concentrated hydrochloric acid, and subjected to catalytic hydrogenation reaction overnight and filtered to remove insolubles, then concentrated to give Compound 8-6 (1.8 g, yield 98.5%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09365499B2 |
| Source dataset | uspto-grants-2016_06 |
| ORD ID | ord-8d0342622ee946f08d7a093ce57df40b |
| Source note | uspto-grants-2016_06 |