Hydrochloric Acid → {spiro[2.5]octan-6-yl}methanamine hydrochloride

HRID 2201666Notes

Reaction equation

HRID 2201666 reaction equation
[CH2:1]1[C:3]2([CH2:8][CH2:7][CH:6]([CH2:9][NH:10]C(=O)OCC3C=CC=CC=3)[CH2:5][CH2:4]2)[CH2:2]1.[ClH:21]>CO.[Pd]>[ClH:21].[CH2:2]1[C:3]2([CH2:8][CH2:7][CH:6]([CH2:9][NH2:10])[CH2:5][CH2:4]2)[CH2:1]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 71243330HCID 71243330, compound

Product 1

HCID 68704587{spiro[2.5]octan-6-yl}methanamine hydrochlorideYield 98.5%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

Compound 8-5 (2.85 g, 10.4 mmol) was dissolved in 30 mL of methanol, added 0.2 g of palladium on carbon and 1 mL of concentrated hydrochloric acid, and subjected to catalytic hydrogenation reaction overnight and filtered to remove insolubles, then concentrated to give Compound 8-6 (1.8 g, yield 98.5%).

Workup

  1. customsubjected to catalytic hydrogenation reaction overnight
  2. filtrationfiltered
  3. customto remove insolubles
  4. concentrationconcentrated

Sources & evidence

ORD record
ord-8d0342622ee946f08d7a093ce57df40b
Source dataset
uspto-grants-2016_06
Patent number
US09365499B2

Reaction notes

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