HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → HCID 86723566, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | HCID 71306149 | HCID 71306149 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 86723566 | HCID 86723566 | 99.6% |
Reaction Steps
tert-Butyl 4-azaspiro[2.4]heptane-4-carboxylate (Compound 11-1) (0.75 g, 3.80 mmol) and TFA (3 mL) were added in DCM (10 mL) and the mixture was stirred at room temperature for 1 hour and concentrated to give Compound 11-2 (800 mg, 99.6%) as a yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09365499B2 |
| Source dataset | uspto-grants-2016_06 |
| ORD ID | ord-22dca00a3c0a41d6ae4fa6c90c5bd804 |
| Source note | uspto-grants-2016_06 |