Trifluoroacetic acid → HCID 86723566, compound

HRID 2201667Notes

Reaction equation

HRID 2201667 reaction equation
[CH2:1]1[C:3]2([CH2:7][CH2:6][CH2:5][N:4]2C(OC(C)(C)C)=O)[CH2:2]1.[C:15]([OH:21])([C:17]([F:20])([F:19])[F:18])=[O:16]>C(Cl)Cl>[F:18][C:17]([F:20])([F:19])[C:15]([OH:21])=[O:16].[CH2:2]1[C:3]2([CH2:7][CH2:6][CH2:5][NH:4]2)[CH2:1]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 71306149HCID 71306149, compound2×

Product 1

HCID 86723566HCID 86723566, compoundYield 99.6%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

tert-Butyl 4-azaspiro[2.4]heptane-4-carboxylate (Compound 11-1) (0.75 g, 3.80 mmol) and TFA (3 mL) were added in DCM (10 mL) and the mixture was stirred at room temperature for 1 hour and concentrated to give Compound 11-2 (800 mg, 99.6%) as a yellow oil.

Workup

  1. concentrationconcentrated

Sources & evidence

ORD record
ord-22dca00a3c0a41d6ae4fa6c90c5bd804
Source dataset
uspto-grants-2016_06
Patent number
US09365499B2

Reaction notes

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