反应详情

A solution of tert-butyl (5-(cyclopent-1-en-1-yl)-2-nitrophenyl)carbamate (4.3 g, 14.13 mmol, 1.0 equiv.) in dichloromethane (50 mL) was added TFA (10 mL) at room temperature. The reaction mixture was stirred at room temperature for 2 h. The reaction was then evaporated under reduced pressure. The crude residue was quenched with a saturated solution of sodium bicarbonate. The product was extracted with ethyl acetate, washed with water and brine, dried, filtered and concentrated under reduced pressure. The crude residue was purified by column chromatography (silica gel, 60% EtOAc/hexanes) to give 5-(cyclopent-1-en-1-yl)-2-nitroaniline (2.5 g, 87% yield).

1. customThe reaction was then evaporated under reduced pressure
2. customThe crude residue was quenched with a saturated solution of sodium bicarbonate
3. extractionThe product was extracted with ethyl acetate
4. washwashed with water and brine
5. customdried
6. filtrationfiltered
7. concentrationconcentrated under reduced pressure
8. customThe crude residue was purified by column chromatography (silica gel, 60% EtOAc/hexanes)