Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Picolinic acid → Diethyl 2-(5-bromopyridin-2-yl)malonate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Picolinic acid | HCID 1018 | — |
| 반응물 | Diethyl Malonate | HCID 7761 | — |
| 반응물 | Cesium carbonate | HCID 10796 | — |
| 반응물 | 5-Bromo-2-iodopyridine | HCID 593690 | — |
| 촉매 | Copper | HCID 23978 | — |
| 촉매 | Copper iodide | HCID 83717 | — |
| 용매 | 1,4-Dioxane | HCID 31275 | — |
| 생성물 | Diethyl 2-(5-bromopyridin-2-yl)malonate | HCID 59238270 | — |
반응 단계
2-(5-Bromo-pyridin-2-yl)-malonic acid diethyl ester (XXXVI) is prepared by copper-catalyzed reaction with malonic acid diethyl ester. The reaction is typically performed by mixing XXXV with malonic acid diethyl ester, copper iodide, cesium carbonate, and pyridine-2-carboxylic acid in 1,4-dioxane and heating to 70 degrees Celsius for 24 hours under nitrogen atmosphere.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08202866B2 |
| 출처 데이터셋 | uspto-grants-2012_06 |
| ORD ID | ord-4a0d2e13f2e54af8857cd02a2ed3add9 |
| 출처 메모 | uspto-grants-2012_06 |