HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Hydrochloric Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | HCID 71003970 | HCID 71003970 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | Hydrochloric Acid | HCID 313 | 100% |
| Product | HCID 86692161 | HCID 86692161 | — |
Reaction Steps
To tert-butyl 2-(3-benzyl-1-oxoisoindolin-5-yloxy)ethylcarbamate (426 mg, 1.11 mmol) was added 3 mL of dioxane and 3 mL of 4N HCl in dioxane at room temperature, this was stirred for 3 hours, then concentrated down to give 5-(2-aminoethoxy)-3-benzylisoindolin-1-one hydrochloride as HCl salt (355 mg, 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09365512B2 |
| Source dataset | uspto-grants-2016_06 |
| ORD ID | ord-088501a12e02492ca59aaf3da1f9097a |
| Source note | uspto-grants-2016_06 |