Hydrochloric Acid → Hydrochloric Acid

HRID 2201755Notes

Reaction equation

HRID 2201755 reaction equation
[CH2:1]([CH:8]1[C:16]2[C:11](=[CH:12][CH:13]=[C:14]([O:17][CH2:18][CH2:19][NH:20]C(=O)OC(C)(C)C)[CH:15]=2)[C:10](=[O:28])[NH:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:29]>O1CCOCC1>[ClH:29].[NH2:20][CH2:19][CH2:18][O:17][C:14]1[CH:15]=[C:16]2[C:11](=[CH:12][CH:13]=1)[C:10](=[O:28])[NH:9][CH:8]2[CH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:29]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 71003970HCID 71003970, compound

Product 2

HCID 313Hydrochloric AcidYield 100%HCID 86692161HCID 86692161, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

To tert-butyl 2-(3-benzyl-1-oxoisoindolin-5-yloxy)ethylcarbamate (426 mg, 1.11 mmol) was added 3 mL of dioxane and 3 mL of 4N HCl in dioxane at room temperature, this was stirred for 3 hours, then concentrated down to give 5-(2-aminoethoxy)-3-benzylisoindolin-1-one hydrochloride as HCl salt (355 mg, 100%).

Workup

  1. concentrationconcentrated down

Sources & evidence

ORD record
ord-088501a12e02492ca59aaf3da1f9097a
Source dataset
uspto-grants-2016_06
Patent number
US09365512B2

Reaction notes

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