Thionyl Chloride → 2,6-Dichloro-4-(methylcarbamoyl)benzoyl chloride
Reaction equation
[Cl:1][C:2]1[CH:10]=[C:9]([C:11](=[O:14])[NH:12][CH3:13])[CH:8]=[C:7]([Cl:15])[C:3]=1[C:4](O)=[O:5].S(Cl)([Cl:18])=O>ClCCl>[Cl:1][C:2]1[CH:10]=[C:9]([C:11](=[O:14])[NH:12][CH3:13])[CH:8]=[C:7]([Cl:15])[C:3]=1[C:4]([Cl:18])=[O:5]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 50 °C
Procedure
A mixture of 2,6-dichloro-4-(methylcarbamoyl)benzoic acid (400 mg, 1.6 mmol) and thionyl chloride (1.91 g, 16 mmol) in dichloromethane (10 mL) was stirred at 50° C. for 5 hours. The reaction mixture was concentrated under rotary evaporator and used as such for next step.
Workup
- concentrationThe reaction mixture was concentrated under rotary evaporator
Sources & evidence
- ORD record
- ord-c721ab444c494f1181f3d9ce3afef53d
- Source dataset
- uspto-grants-2016_06
- Patent number
- US09364466B2
Reaction notes
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