Water → HCID 15284104, compound

HRID 22018Notes

Reaction equation

HRID 22018 reaction equation
[C:1]([CH:6]1[CH2:15][CH2:14][C:13]2[NH:12][C:11](=[O:16])[N:10]3[CH:17]=[C:18]([C:20]4[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=4[F:26])[N:19]=[C:9]3[C:8]=2[CH2:7]1)([O:3]CC)=O.O>O1CCCC1>[C:6]1([C:1]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)([OH:3])[CH:6]2[CH2:15][CH2:14][C:13]3[NH:12][C:11](=[O:16])[N:10]4[CH:17]=[C:18]([C:20]5[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=5[F:26])[N:19]=[C:9]4[C:8]=3[CH2:7]2)[CH:15]=[CH:14][CH:13]=[CH:8][CH:7]=1

Participants

4

Reactant 2

HCID 962WaterHCID 99285709-Carboethoxy-2-(2-fluorophenyl)-7,8,9,10-tetrahydro-imidazo[1,2-c]-quinazolin-5(6H)-one

Product 1

HCID 15284104HCID 15284104, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a solution of 9-Carboethoxy-2-(2-fluorophenyl)-7,8,9,10-tetrahydro-imidazo[1,2-c]-quinazolin-5(6H)-one (110 mg) in 15 mL of anhydrous tetrahydrofuran was added 2 mL of 1.8M phenylithium. The reaction was allowed to stand for 15 minutes and then quenched with 1 mL of 10% acetic acid. The solvent was removed in vacuo and the crude reaction mixture triterated with water. The solid was then collected and dried to yield 9-(Diphenylhydroxymethyl)-2-(2-fluorophenyl)-7,8,9,10-tetrahydro-imidazo [1,2-c]-quinazolin-5(6H)-one (Compound 46), m.p. 315°-318° C.

Workup

  1. customquenched with 1 mL of 10% acetic acid
  2. customThe solvent was removed in vacuo
  3. customthe crude reaction mixture
  4. customThe solid was then collected
  5. customdried

Sources & evidence

ORD record
ord-486da381e8a841509af93a248b651f39
Source dataset
uspto-grants-1995_06
Patent number
US05426186

Reaction notes

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