HuagongsheHuagongshe Chemistry Print Report · For research reference only
Oxalyl chloride → 1-[(4-Fluorophenyl)carbamoyl]cyclopropanecarbonyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | 1-[(4-Fluorophenyl)carbamoyl]cyclopropanecarboxylic Acid | HCID 21081530 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 1-[(4-Fluorophenyl)carbamoyl]cyclopropanecarbonyl chloride | HCID 58083267 | — |
Reaction Steps
Oxalyl chloride (12.6 kg) was added to a solution of 1-(4-fluoro-phenylcarbamoyl)-cyclopropanecarboxylic acid (22.8 kg) in a mixture of THF (96.1 kg) and N,N-dimethylformamide (DMF; 0.23 kg) at a rate such that the batch temperature did not exceed 25° C. This solution was used in the next step without further processing.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09365516B2 |
| Source dataset | uspto-grants-2016_06 |
| ORD ID | ord-6020a6cc2ba9416d8aa1cad6620bc421 |
| Source note | uspto-grants-2016_06 |