HRID2201893

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID65578

Ethanedioyl dichloride

C2Cl2O2

HCID21081530

1-[(4-Fluorophenyl)carbamoyl]cyclopropane-1-carboxylic acid

C11H10FNO3

PRODUCTS

生成物

HCID58083267

1-[[(4-Fluorophenyl)amino]carbonyl]cyclopropanecarbonyl chloride

C11H9ClFNO2

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

溶剂HCID8028

Tetrahydrofuran

C4H8O

PROCEDURE

实验过程

Oxalyl chloride (12.6 kg) was added to a solution of 1-(4-fluoro-phenylcarbamoyl)-cyclopropanecarboxylic acid (22.8 kg) in a mixture of THF (96.1 kg) and N,N-dimethylformamide (DMF; 0.23 kg) at a rate such that the batch temperature did not exceed 25° C. This solution was used in the next step without further processing.

WORKUP

后处理

customdid not exceed 25° C