Hydrochloric Acid → 4-[3-(4-chlorophenyl)-1H-pyrazol-5-yl]piperidine

Participants

Reaction Steps

INTERMEDIATE 7 was obtained by removal of the Boc group of INTERMEDIATE 1 with an acid. To a solution of INTERMEDIATE 1 (2.5 g, 6.92 mmol) in dichloromethane (10 mL) was added 4 M HCl (10 mL, 40 mmol in dioxane). The mixture was stirred at room temperature overnight. Solvent was evaporated under reduced pressure, and the residue was dried under vacuum.

Provenance & Evidence