Hydrochloric Acid → 4-[3-(4-Chlorophenyl)-1H-pyrazol-5-yl]piperidine

HRID 2202151Notes

Reaction equation

HRID 2202151 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:12]=[C:11]([CH:13]3[CH2:18][CH2:17][N:16](C(OC(C)(C)C)=O)[CH2:15][CH2:14]3)[NH:10][N:9]=2)=[CH:4][CH:3]=1.Cl>ClCCl>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:12]=[C:11]([CH:13]3[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]3)[NH:10][N:9]=2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 7075709HCID 7075709, compound

Product 1

HCID 4491264-[3-(4-Chlorophenyl)-1H-pyrazol-5-yl]piperidine

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

INTERMEDIATE 7 was obtained by removal of the Boc group of INTERMEDIATE 1 with an acid. To a solution of INTERMEDIATE 1 (2.5 g, 6.92 mmol) in dichloromethane (10 mL) was added 4 M HCl (10 mL, 40 mmol in dioxane). The mixture was stirred at room temperature overnight. Solvent was evaporated under reduced pressure, and the residue was dried under vacuum.

Workup

  1. customSolvent was evaporated under reduced pressure
  2. customthe residue was dried under vacuum

Sources & evidence

ORD record
ord-cda3817722e7482f9746793aec41522b
Source dataset
uspto-grants-2016_06
Patent number
US09365539B2

Reaction notes

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