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Pentanenitrile, 4,4-dimethyl-3-oxo- → 4-(5-Amino-3-tert-butyl-1H-pyrazol-1-yl)benzonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Pentanenitrile, 4,4-dimethyl-3-oxo- | HCID 108871 | — |
| 反応物 | 4-Cyanophenylhydrazine Hydrochloride | HCID 16212962 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 4-(5-Amino-3-tert-butyl-1H-pyrazol-1-yl)benzonitrile | HCID 7147083 | 82.1% |
反応手順
A flask was charged with 4-hydrazinylbenzonitrile hydrochloride (0.70 g, 3.8 mmol.), 4,4-dimethyl-3-oxopentanenitrile (0.48 g, 3.8 mmol) and MeOH and the reaction was heated at refluxed overnight. The reaction was cooled, and the solids which formed upon cooling were filtered off and discarded. Additional solids formed upon further standing (product) along with product material in solution. The solution containing, the solids was concentrated to yield 0.75 g of solid product (92%). MS M+1 (241).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08202899B2 |
| 出典データセット | uspto-grants-2012_06 |
| ORD ID | ord-47f23733431e4f64928cf6f1025ffbcb |
| 出典メモ | uspto-grants-2012_06 |