HCID 178487603, Verbindung → HCID 178487602, Verbindung

HRID 2202326Notizen

Reaktionsgleichung

[S:1]([OH:5])([OH:4])(=[O:3])=[O:2].[F:6][C:7]1[CH:8]=[C:9]([NH:18][C:19]([C@@H:21]2[N:30]([C:31]([C@@H:33]3[CH2:36][C@H:35]([CH2:37][C:38]([OH:40])=[O:39])[CH2:34]3)=[O:32])[CH2:29][CH2:28][C:27]3[N:26]=[C:25]([O:41][CH3:42])[CH:24]=[CH:23][C:22]2=3)=[O:20])[CH:10]=[C:11]2[C:15]=1[C:14]([CH3:17])([CH3:16])[CH2:13][CH2:12]2>CCC(C)=O>[OH2:2].[S:1]([OH:5])([OH:4])(=[O:3])=[O:2].[F:6][C:7]1[CH:8]=[C:9]([NH:18][C:19]([C@@H:21]2[N:30]([C:31]([C@@H:33]3[CH2:36][C@H:35]([CH2:37][C:38]([OH:40])=[O:39])[CH2:34]3)=[O:32])[CH2:29][CH2:28][C:27]3[N:26]=[C:25]([O:41][CH3:42])[CH:24]=[CH:23][C:22]2=3)=[O:20])[CH:10]=[C:11]2[C:15]=1[C:14]([CH3:17])([CH3:16])[CH2:13][CH2:12]2.[F:6][C:7]1[CH:8]=[C:9]([NH:18][C:19]([C@@H:21]2[N:30]([C:31]([C@@H:33]3[CH2:36][C@H:35]([CH2:37][C:38]([OH:40])=[O:39])[CH2:34]3)=[O:32])[CH2:29][CH2:28][C:27]3[N:26]=[C:25]([O:41][CH3:42])[CH:24]=[CH:23][C:22]2=3)=[O:20])[CH:10]=[C:11]2[C:15]=1[C:14]([CH3:17])([CH3:16])[CH2:13][CH2:12]2.[S:1]([OH:5])([OH:4])(=[O:3])=[O:2]

Komponenten

Reaktionsbedingungen

Temperatur: 60 °C

Versuchsvorschrift

The obtained (cis-3-(((5R)-5-((7-fluoro-1,1-dimethyl-2,3-dihydro-1H-inden-5-yl)carbamoyl)-2-methoxy-7,8-dihydro-1,6-naphthyridin-6(5H)-yl)carbonyl)cyclobutyl)acetic acid monosulfate (300 mg, 0.49 mmol) was dissolved in MEK (600 μL) while warming at water-bath (60° C.). After changing to an oil, the oil was stood overnight at room temperature. The precipitated white crystals were stood at refrigerator for several weeks to give the title compound.

Aufarbeitung

waitThe precipitated white crystals were stood at refrigerator for several weeks

Quellen und Nachweise

ORD-Eintrag: ord-24c99c374aa84380853959d292ac039c
Quelldatensatz: uspto-grants-2016_06
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US09365520B2

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