Sulfuric acid tetrahydrofuran → HCID 178487612、化合物

HRID 2202327ノート

反応式

HRID 2202327 の反応式
[S:1](=[O:5])(=[O:4])([OH:3])[OH:2].C1COCC1.[F:11][C:12]1[CH:13]=[C:14]([NH:23][C:24]([C@@H:26]2[N:35]([C:36]([C@@H:38]3[CH2:41][C@H:40]([C:42]([OH:44])=[O:43])[CH2:39]3)=[O:37])[CH2:34][CH2:33][C:32]3[N:31]=[C:30]([O:45][CH3:46])[CH:29]=[CH:28][C:27]2=3)=[O:25])[CH:15]=[C:16]2[C:20]=1[C:19]([CH3:22])([CH3:21])[CH2:18][CH2:17]2>C1COCC1>[S:1]([OH:5])([OH:4])(=[O:3])=[O:2].[F:11][C:12]1[CH:13]=[C:14]([NH:23][C:24]([C@@H:26]2[N:35]([C:36]([C@@H:38]3[CH2:41][C@H:40]([C:42]([OH:44])=[O:43])[CH2:39]3)=[O:37])[CH2:34][CH2:33][C:32]3[N:31]=[C:30]([O:45][CH3:46])[CH:29]=[CH:28][C:27]2=3)=[O:25])[CH:15]=[C:16]2[C:20]=1[C:19]([CH3:21])([CH3:22])[CH2:18][CH2:17]2

参加物

4

反応物 2

HCID 68124251Sulfuric acid tetrahydrofuranHCID 178487610HCID 178487610、化合物

生成物 1

HCID 178487612HCID 178487612、化合物収率 92%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

0.126M Sulfuric acid/THF (8.01 mL, 1.01 mmol) solution was added to a solution of cis-3-(((5R)-5-((7-fluoro-1,1-dimethyl-2,3-dihydro-1H-inden-5-yl)carbamoyl)-2-methoxy-7,8-dihydro-1,6-naphthyridin-6(5H)-yl)carbonyl)cyclobutanecarboxylic acid (500 mg, 1.01 mmol) in THF (10 mL) at room temperature. The mixture was concentrated under reduced pressure to dryness, and the solid was collected by filtration with ethyl acetate (10 mL) to give the title compound (548.3 mg, 0.924 mmol, 92%) as a white solid.

後処理

  1. concentrationThe mixture was concentrated under reduced pressure to dryness
  2. filtrationthe solid was collected by filtration with ethyl acetate (10 mL)

出典と根拠

ORDレコード
ord-61955618f7a2421bbcb922a1cfb807fe
出典データセット
uspto-grants-2016_06
特許番号
US09365520B2

反応ノート

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