Trifluoroacetic acid → HCID 68852177, compound

HRID 2202339Notes

Reaction equation

HRID 2202339 reaction equation
[CH2:1]([O:3][CH2:4][C:5]1([OH:18])[CH2:10][CH2:9][N:8](C(OC(C)(C)C)=O)[CH2:7][CH2:6]1)[CH3:2].C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH2:1]([O:3][CH2:4][C:5]1([OH:18])[CH2:6][CH2:7][NH:8][CH2:9][CH2:10]1)[CH3:2]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 722082611-Piperidinecarboxylic acid, 4-(ethoxymethyl)-4-hydroxy-, 1,1-dimethylethyl ester

Product 1

HCID 68852177HCID 68852177, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of tert-butyl 4-(ethoxymethyl)-4-hydroxypiperidine-1-carboxylate (9C, 1 eq.) in DCM was added TFA (10 eq.). The mixture was stirred at r.t. for 0.5 hr, when TLC showed that s.m. was consumed. The mixture was concentrated to give the crude product which was used to the next step without further purification. LC-MS: m/z 160.2 (M+H)+

Workup

  1. customwas consumed
  2. concentrationThe mixture was concentrated

Sources & evidence

ORD record
ord-62ea7f4074ed41c5a223de6f2872fdc7
Source dataset
uspto-grants-2016_06
Patent number
US09365545B2

Reaction notes

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