Trifluoroacetic acid → HCID 90419669, compound

HRID 2202344Notes

Reaction equation

HRID 2202344 reaction equation
[OH:1][C:2]1([CH2:15][C:16]2([CH3:19])[CH2:18][CH2:17]2)[CH2:7][CH2:6][N:5](C(OC(C)(C)C)=O)[CH2:4][CH2:3]1.C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH3:19][C:16]1([CH2:15][C:2]2([OH:1])[CH2:7][CH2:6][NH:5][CH2:4][CH2:3]2)[CH2:17][CH2:18]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 90418906HCID 90418906, compound

Product 1

HCID 90419669HCID 90419669, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of compound 12C (1 eq.) in DCM, was added TFA (10 eq.), the reaction mixture was stirred at room temperature for about 2 hours, when TLC detected no s.m. The reaction mixture was concentrated to afford the desired product 12D. The crude product was used for the next step directly without further purification. LC-MS: m/z 170.3 (M+H)+

Workup

  1. concentrationThe reaction mixture was concentrated

Sources & evidence

ORD record
ord-d631d8dad8a44167bd278a09c56b1e57
Source dataset
uspto-grants-2016_06
Patent number
US09365545B2

Reaction notes

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