Trifluoroacetic acid → HCID 90447577, compound

HRID 2202347Notes

Reaction equation

HRID 2202347 reaction equation
[CH:1]1([CH2:4][C:5]2([OH:18])[CH2:10][CH2:9][N:8](C(OC(C)(C)C)=O)[CH2:7][CH2:6]2)[CH2:3][CH2:2]1.C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH:1]1([CH2:4][C:5]2([OH:18])[CH2:10][CH2:9][NH:8][CH2:7][CH2:6]2)[CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 90419006HCID 90419006, compound

Product 1

HCID 90447577HCID 90447577, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of compound 14B (1 eq.) in DCM, was added TFA (10 eq.), the reaction mixture was stirred at room temperature for about 2 hours, when LCMS detected no s.m. The reaction mixture was concentrated to afford the desired product 14C. The crude product was used for the next step directly without further purification. LC-MS: m/z 156.2 (M+H)+

Workup

  1. concentrationThe reaction mixture was concentrated

Sources & evidence

ORD record
ord-5a33a00d7f7a4a6abde587c9d87e36eb
Source dataset
uspto-grants-2016_06
Patent number
US09365545B2

Reaction notes

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