Hydrochloric Acid → HCID 90447583, compound

HRID 2202353Notes

Reaction equation

HRID 2202353 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][C:11]([OH:21])([CH2:14][C:15]([C:17]([F:20])([F:19])[F:18])=[CH2:16])[CH2:10][CH2:9]1)=O)(C)(C)C.Cl.O1CCOCC1>C(Cl)Cl>[F:20][C:17]([F:18])([F:19])[C:15](=[CH2:16])[CH2:14][C:11]1([OH:21])[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 90418966HCID 90418966, compound

Product 1

HCID 90447583HCID 90447583, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of tert-butyl-4-hydroxy-4-(2-(trifluoromethyl)allyl)piperidine-1-carboxylate 17B (300 mg, 0.97 mmol), in DCM (5 mL) was added a solution of HCl in dioxane (3 M, 1 mL, 3 mmol), and then the mixture was stirred at room temperature for 16 hrs. The mixture was concentrated in vacuo to get the desired compound which was used directly for the next step. LC-MS: m/z 210.2 (M+H)+

Workup

  1. concentrationThe mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-ebbf66973c3443bbaad5aff665a597e6
Source dataset
uspto-grants-2016_06
Patent number
US09365545B2

Reaction notes

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