HCID 90419025, compound → HCID 90418931, compound

HRID 2202387Notes

Reaction equation

HRID 2202387 reaction equation
[F:1][CH:2]([F:19])[CH2:3][CH2:4][C:5]1([OH:18])[CH2:10][CH2:9][N:8](C(OC(C)(C)C)=O)[CH2:7][CH2:6]1>Cl.O1CCOCC1>[F:19][CH:2]([F:1])[CH2:3][CH2:4][C:5]1([OH:18])[CH2:6][CH2:7][NH:8][CH2:9][CH2:10]1

Participants

4

Reactant 1

HCID 90419025HCID 90419025, compound

Product 1

HCID 90418931HCID 90418931, compoundYield 156.2%

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 312751,4-DioxaneSolvent

Procedure

A solution of tert-butyl 4-(3,3-difluoropropyl)-4-hydroxypiperidine-1-carboxylate (293 mg, 1.075 mmol) in 5 mL of 3.5 N HCl in dioxane was stirred at r.t. for 30 min. The reaction mixture was concentrated in vacuo to give 301 mg of the title product which was used in the next step directly.

Workup

  1. concentrationThe reaction mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-ad01205cdbf243d0be50c056c80caef5
Source dataset
uspto-grants-2016_06
Patent number
US09365545B2

Reaction notes

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