HCID 90418922, compound → HCID 90418895, compound

HRID 2202389Notes

Reaction equation

HRID 2202389 reaction equation
[F:1][CH:2]([F:19])/[CH:3]=[CH:4]/[C:5]1([OH:18])[CH2:10][CH2:9][N:8](C(OC(C)(C)C)=O)[CH2:7][CH2:6]1>Cl.O1CCOCC1>[F:19][CH:2]([F:1])/[CH:3]=[CH:4]/[C:5]1([OH:18])[CH2:6][CH2:7][NH:8][CH2:9][CH2:10]1

Participants

4

Reactant 1

HCID 90418922HCID 90418922, compound

Product 1

HCID 90418895HCID 90418895, compoundYield 157.5%

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 312751,4-DioxaneSolvent

Procedure

A solution of (E)-tert-butyl 4-(3,3-difluoroprop-1-enyl)-4-hydroxypiperidine-1-carboxylate (38C) (293 mg, 1.075 mmol) in 5 mL of 3.5 N HCl in dioxane was stirred at r.t. for 30 min. The reaction mixture was concentrated in vacuo to give 300 mg of the title product as a yellow liquid which was used in the next step directly.

Workup

  1. concentrationThe reaction mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-59b094e0ac134a438848e59b5e62ef9b
Source dataset
uspto-grants-2016_06
Patent number
US09365545B2

Reaction notes

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