Hydrochloric Acid → HCID 89599432, compound

HRID 2202440Notes

Reaction equation

HRID 2202440 reaction equation
[Br:1][C:2]1[C:23]([N:24]2[CH2:29][CH2:28][N:27]([CH:30]3[CH2:33][O:32][CH2:31]3)[CH2:26][CH2:25]2)=[CH:22][C:5]2[C:6]([CH3:21])([CH3:20])[C:7]3[NH:8][C:9]4[C:14]([C:15]=3[C:16](=[O:17])[C:4]=2[CH:3]=1)=[CH:13][CH:12]=[C:11]([C:18]#[N:19])[CH:10]=4.[ClH:34]>CS(C)=O>[ClH:34].[Br:1][C:2]1[C:23]([N:24]2[CH2:25][CH2:26][N:27]([CH:30]3[CH2:33][O:32][CH2:31]3)[CH2:28][CH2:29]2)=[CH:22][C:5]2[C:6]([CH3:21])([CH3:20])[C:7]3[NH:8][C:9]4[C:14]([C:15]=3[C:16](=[O:17])[C:4]=2[CH:3]=1)=[CH:13][CH:12]=[C:11]([C:18]#[N:19])[CH:10]=4

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 49806588HCID 49806588, compound

Product 1

HCID 89599432HCID 89599432, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

9-Bromo-6,6-dimethyl-8-(4-oxetan-3-yl-piperazin-1-yl)-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile was added with 1.05 eq. of 6 N hydrochloric acid and DMSO and dissolved therein. After freeze-drying, the mixture was crystallized from ethanol containing 25% water to give 9-bromo-6,6-dimethyl-8-(4-oxetan-3-yl-piperazin-1-yl)-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile monohydrochloride salt.

Workup

  1. dissolutiondissolved
  2. customAfter freeze-drying
  3. customthe mixture was crystallized from ethanol containing 25% water

Sources & evidence

ORD record
ord-bec1aa780c734eb79da87779a66b2e35
Source dataset
uspto-grants-2016_06
Patent number
US09365514B2

Reaction notes

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