Methanesulfonic Acid → HCID 86686435, compound

HRID 2202444Notes

Reaction equation

HRID 2202444 reaction equation
[CH3:1][C:2]1([CH3:35])[C:14]2[NH:13][C:12]3[C:7](=[CH:8][CH:9]=[C:10]([C:15]#[N:16])[CH:11]=3)[C:6]=2[C:5](=[O:17])[C:4]2[CH:18]=[C:19]([CH3:34])[C:20]([N:22]3[CH2:27][CH2:26][CH:25]([N:28]4[CH2:33][CH2:32][O:31][CH2:30][CH2:29]4)[CH2:24][CH2:23]3)=[CH:21][C:3]1=2.[CH3:36][S:37]([OH:40])(=[O:39])=[O:38]>CS(C)=O>[CH3:36][S:37]([OH:40])(=[O:39])=[O:38].[CH3:1][C:2]1([CH3:35])[C:14]2[NH:13][C:12]3[C:7](=[CH:8][CH:9]=[C:10]([C:15]#[N:16])[CH:11]=3)[C:6]=2[C:5](=[O:17])[C:4]2[CH:18]=[C:19]([CH3:34])[C:20]([N:22]3[CH2:23][CH2:24][CH:25]([N:28]4[CH2:29][CH2:30][O:31][CH2:32][CH2:33]4)[CH2:26][CH2:27]3)=[CH:21][C:3]1=2

Participants

4

Reactant 2

HCID 6395Methanesulfonic AcidHCID 498067226,6,9-Trimethyl-8-(4-morpholin-4-yl-piperidin-1-yl)-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile

Product 1

HCID 86686435HCID 86686435, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

6,6,9-Trimethyl-8-(4-morpholin-4-yl-piperidin-1-yl)-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile was added with 1.05 eq. of 2 N methane sulfonic acid and DMSO and dissolved therein. After freeze-drying, the mixture was crystallized from ethanol to give 6,6,9-trimethyl-8-(4-morpholin-4-yl-piperidin-1-yl)-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile methane sulfonic acid salt.

Workup

  1. dissolutiondissolved
  2. customAfter freeze-drying
  3. customthe mixture was crystallized from ethanol

Sources & evidence

ORD record
ord-5169746126aa4c22ad9eb3bc1e034547
Source dataset
uspto-grants-2016_06
Patent number
US09365514B2

Reaction notes

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