huagongshe.com
HRID2202448

反应详情

EQUATION

反应方程式

HRID 2202448 的结构方程式

REACTANTS

反应物

2
结构：CC(C)N1CCNCC1
HCID78013

Piperazine, 1-isopropyl-

C7H16N2

结构：CC1(C)c2cc(OS(=O)(=O)C(F)(F)F)ccc2C(=O)c2c1[nH]c1cc(C#N)ccc21
HCID86663817

未命名化合物

2 次

PRODUCTS

生成物

1
结构：CC(C)N1CCN(c2ccc3c(c2)C(C)(C)c2[nH]c4cc(C#N)ccc4c2C3=O)CC1
HCID49805004

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CN1CCCC1=O
溶剂HCID13387

N-Methyl-2-pyrrolidone

C5H9NO

CONDITIONS

反应条件

温度
120 °C

PROCEDURE

实验过程

Trifluoro-methane sulfonic acid 3-cyano-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazol-8-yl ester (Compound B1, 40 mg, 0.0921 mmol) was dissolved in NMP (1 ml) and added with 1-isopropylpiperazine (236 mg, 20 eq.). The mixture was stirred at 120° C. for 3 hours. After cooling to room temperature, purification was carried out by HPLC to obtain the target compound (white powder, 12.8 mg, 34%).

WORKUP

后处理

  1. temperatureAfter cooling to room temperature
  2. custompurification
  3. customto obtain the target compound (white powder, 12.8 mg, 34%)