Hydrochloric Acid → HCID 86686437, compound

HRID 2202449Notes

Reaction equation

HRID 2202449 reaction equation
[CH:1]1([N:5]2[CH2:10][CH2:9][N:8]([C:11]3[C:12]([CH:33]4[CH2:35][CH2:34]4)=[CH:13][C:14]4[C:26](=[O:27])[C:25]5[C:24]6[C:19](=[CH:20][C:21]([C:28]#[N:29])=[CH:22][CH:23]=6)[NH:18][C:17]=5[C:16]([CH3:31])([CH3:30])[C:15]=4[CH:32]=3)[CH2:7][CH2:6]2)[CH2:4][CH2:3][CH2:2]1.[ClH:36]>CS(C)=O>[ClH:36].[CH:1]1([N:5]2[CH2:10][CH2:9][N:8]([C:11]3[C:12]([CH:33]4[CH2:35][CH2:34]4)=[CH:13][C:14]4[C:26](=[O:27])[C:25]5[C:24]6[C:19](=[CH:20][C:21]([C:28]#[N:29])=[CH:22][CH:23]=6)[NH:18][C:17]=5[C:16]([CH3:31])([CH3:30])[C:15]=4[CH:32]=3)[CH2:7][CH2:6]2)[CH2:2][CH2:3][CH2:4]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 49805003HCID 49805003, compound

Product 1

HCID 86686437HCID 86686437, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

8-(4-Cyclobutyl-piperazin-1-yl)-9-cyclopropyl-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile was added with 1.05 eq. of 6 N hydrochloric acid and DMSO and dissolved therein. After freeze-drying, the mixture was crystallized from ethanol containing 25% water to give 8-(4-cyclobutyl-piperazin-1-yl)-9-cyclopropyl-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile monohydrochloride salt.

Workup

  1. dissolutiondissolved
  2. customAfter freeze-drying
  3. customthe mixture was crystallized from ethanol containing 25% water

Sources & evidence

ORD record
ord-11ea07979e834ed486656397c8d1e9a2
Source dataset
uspto-grants-2016_06
Patent number
US09365514B2

Reaction notes

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