HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-bromo-1-(4-methylsulfonyl-phenyl)-1H-benzo[d]imidazole → 6-[2-(4-Fluoro-phenyl)-2H-pyrazol-3-yl]-1-(4-methanesulfonyl-phenyl)-1H-benzoimidazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-bromo-1-(4-methylsulfonyl-phenyl)-1H-benzo[d]imidazole | HCID 90094953 | — |
| Reactant | 1-(4-Fluorophenyl)-1H-pyrazol-5-ylboronic acid | HCID 90095170 | — |
| Product | 6-[2-(4-Fluoro-phenyl)-2H-pyrazol-3-yl]-1-(4-methanesulfonyl-phenyl)-1H-benzoimidazole | HCID 73671981 | — |
Reaction Steps
The title compound, white solid (12 mg, 14%), MS (ISP) m/z=433.4 [(M+H)+], mp 247° C., was prepared in accordance with the general method of example 1 from 6-bromo-1-(4-methylsulfonyl-phenyl)-1H-benzo[d]imidazole (intermediate O) (70 mg, 199 μmol) and 1-(4-fluoro-phenyl)-1H-pyrazol-5-ylboronic acid (intermediate A) (49.2 mg, 239 μmol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09365550B2 |
| Source dataset | uspto-grants-2016_06 |
| ORD ID | ord-49d7bb683f384fc8950e9bdee1ffdcb7 |
| Source note | uspto-grants-2016_06 |