Sodium Hydroxide → HCID 70648092, compound

HRID 2202582Notes

Reaction equation

HRID 2202582 reaction equation
C[O:2][C:3]([C:5]1[N:6](C(OC(C)(C)C)=O)[C:7]([CH2:10][N:11]2[CH2:16][CH2:15][CH:14]([O:17][CH:18]([C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=3)[C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[CH2:13][CH2:12]2)=[CH:8][CH:9]=1)=[O:4].[OH-].[Na+]>CO>[CH:18]([O:17][CH:14]1[CH2:13][CH2:12][N:11]([CH2:10][C:7]2[NH:6][C:5]([C:3]([OH:4])=[O:2])=[CH:9][CH:8]=2)[CH2:16][CH2:15]1)([C:25]1[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=1)[C:19]1[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 86680286HCID 86680286, compound

Product 1

HCID 70648092HCID 70648092, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Into a 50-mL recovery flask (eggplant flask), 790 mg (1.5 mmol) of 5-(4-benzhydryloxypiperidin-1-ylmethyl)pyrrole-1,2-dicarboxylic acid1-tert-butyl ester 2-methyl ester synthesized in Production Example 49 and 20 mL of methanol were fed, and the mixture was stirred under a room temperature. Then, 6.0 mL (6.0 mmol, 4.0 eq.) of a 1-N sodium hydroxide aqueous solution was dropped thereinto, and the mixture was stirred all night at an internal temperature of 60° C.

Workup

  1. stirringthe mixture was stirred all night at an internal temperature of 60° C.

Sources & evidence

ORD record
ord-c077516cd7284122af297e62303e93fb
Source dataset
uspto-grants-2016_06
Patent number
US09365553B2

Reaction notes

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