Sodium Hydroxide → HCID 70648092, compound

Participants

Reaction Steps

Into a 50-mL recovery flask (eggplant flask), 790 mg (1.5 mmol) of 5-(4-benzhydryloxypiperidin-1-ylmethyl)pyrrole-1,2-dicarboxylic acid1-tert-butyl ester 2-methyl ester synthesized in Production Example 49 and 20 mL of methanol were fed, and the mixture was stirred under a room temperature. Then, 6.0 mL (6.0 mmol, 4.0 eq.) of a 1-N sodium hydroxide aqueous solution was dropped thereinto, and the mixture was stirred all night at an internal temperature of 60° C.

Provenance & Evidence