反应详情

To a solution of 3 g of N-(3,3-diethoxy-propyl)-3-methoxy-2-methoxymethyl-2-methyl-propionamide in 71 mL of acetone was added 3.91 g of TsOH.H2O. The mixture was stirred over night at rt, quenched with sat.-NaHCO3 and extracted with DCM. The organic phase was washed with brine, dried over anh. Na2SO4 and concentrated in vacuo. The resulting crude material was purified by CC using heptane/EtOAc from 100/0 to 0/100 as eluant to yield 2.19 g of 3-methoxy-2-methoxymethyl-2-methyl-N-(3-oxo-propyl)-propionamide

1. customquenched with sat.-NaHCO3
2. extractionextracted with DCM
3. washThe organic phase was washed with brine
4. dry with materialdried over anh. Na2SO4
5. concentrationconcentrated in vacuo
6. customThe resulting crude material was purified by CC