Water → 5-amino-3-((3-chlorophenyl)amino)-1H-pyrazole-4-carboxamide

HRID 2202608노트

반응식

HRID 2202608 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([NH:8][C:9](SC)=[C:10]([C:14]#[N:15])[C:11]([NH2:13])=O)[CH:5]=[CH:6][CH:7]=1.[NH2:18][NH2:19].[OH2:20]>CCO>[NH2:13][C:11]1[NH:19][N:18]=[C:9]([NH:8][C:4]2[CH:5]=[CH:6][CH:7]=[C:2]([Cl:1])[CH:3]=2)[C:10]=1[C:14]([NH2:15])=[O:20]

참가 물질

5

반응물 3

HCID 962WaterHCID 9321HydrazineHCID 866989553-((3-Chlorophenyl)amino)-2-cyano-3-(methylthio)acrylamide

생성물 1

HCID 866989565-amino-3-((3-chlorophenyl)amino)-1H-pyrazole-4-carboxamide수율 72%

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
70 °C

실험 절차

A mixture of compound 3 (75 mg, 0.32 mmol) and hydrazine (15 mg, 0.48 mmol) in EtOH (4 mL) was stirred at 70° C. overnight. After the addition of water, the reaction mixture was cooled in an ice bath for 1 hr. The resulting solid was filtered, washed with water, and dried to give compound 4 (50 mg, 72% yield, 100% purity) as a white solid.

후처리

  1. temperaturethe reaction mixture was cooled in an ice bath for 1 hr
  2. filtrationThe resulting solid was filtered
  3. washwashed with water
  4. customdried

출처 및 근거

ORD 기록
ord-daccfa70e75f4ee7836bee22bab1e3e1
출처 데이터셋
uspto-grants-2016_06
특허 번호
US09365556B2

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