HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2202608Generated: October 25, 2026
Water → 5-amino-3-((3-chlorophenyl)amino)-1H-pyrazole-4-carboxamide
https://huagongshe.com/reaction/2202608
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Hydrazine | HCID 9321 | — |
| Reactant | 3-((3-Chlorophenyl)amino)-2-cyano-3-(methylthio)acrylamide | HCID 86698955 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 5-amino-3-((3-chlorophenyl)amino)-1H-pyrazole-4-carboxamide | HCID 86698956 | 72% |
Reaction Steps
A mixture of compound 3 (75 mg, 0.32 mmol) and hydrazine (15 mg, 0.48 mmol) in EtOH (4 mL) was stirred at 70° C. overnight. After the addition of water, the reaction mixture was cooled in an ice bath for 1 hr. The resulting solid was filtered, washed with water, and dried to give compound 4 (50 mg, 72% yield, 100% purity) as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09365556B2 |
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| Source dataset | uspto-grants-2016_06 |
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| ORD ID | ord-daccfa70e75f4ee7836bee22bab1e3e1 |
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| Source note | uspto-grants-2016_06 |
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