Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Hydrazine hydrate (1:1) | HCID 24654 | — |
| Reactant | HCID 1704483 | HCID 1704483 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 86698958 | HCID 86698958 | — |
Reaction Steps
2-((methylthio)(pyridin-3-ylamino)methylene)malononitrile (0.4 g) was dissolved in EtOH (15 mL) and hydrazine hydrate (1.5 eq., 0.086 mL) was added. Reaction was stirred at 70° C. until complete by HPLC (absence of starting material, 18 hrs) and was brought to room temperature. 20 mL of H2O was then added and precipitate formed which was filtered to obtain 5-amino-3-(pyridin-3-ylamino)-1H-pyrazole-4-carbonitrile as a yellow powder.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09365556B2 |
|---|
| Source dataset | uspto-grants-2016_06 |
|---|
| ORD ID | ord-019fed5d900e4ea9b9d63c74e07fb747 |
|---|
| Source note | uspto-grants-2016_06 |
|---|
