Water → HCID 86698958, compound

HRID 2202614Notes

Reaction equation

HRID 2202614 reaction equation
CS[C:3]([NH:9][C:10]1[CH:11]=[N:12][CH:13]=[CH:14][CH:15]=1)=[C:4]([C:7]#[N:8])[C:5]#[N:6].O.[NH2:17][NH2:18].O>CCO>[NH2:6][C:5]1[NH:18][N:17]=[C:3]([NH:9][C:10]2[CH:11]=[N:12][CH:13]=[CH:14][CH:15]=2)[C:4]=1[C:7]#[N:8]

Participants

5

Reactant 3

HCID 962WaterHCID 24654Hydrazine hydrate (1:1)HCID 1704483HCID 1704483, compound

Product 1

HCID 86698958HCID 86698958, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
70 °C

Procedure

2-((methylthio)(pyridin-3-ylamino)methylene)malononitrile (0.4 g) was dissolved in EtOH (15 mL) and hydrazine hydrate (1.5 eq., 0.086 mL) was added. Reaction was stirred at 70° C. until complete by HPLC (absence of starting material, 18 hrs) and was brought to room temperature. 20 mL of H2O was then added and precipitate formed which was filtered to obtain 5-amino-3-(pyridin-3-ylamino)-1H-pyrazole-4-carbonitrile as a yellow powder.

Workup

  1. customReaction
  2. customwas brought to room temperature
  3. customprecipitate formed which
  4. filtrationwas filtered

Sources & evidence

ORD record
ord-019fed5d900e4ea9b9d63c74e07fb747
Source dataset
uspto-grants-2016_06
Patent number
US09365556B2

Reaction notes

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