Hydrazine hydrate (1:1) → HCID 4164367, compound

HRID 2202619Notes

Reaction equation

HRID 2202619 reaction equation
CS[C:3]([NH:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)=[C:4]([C:7]#[N:8])[C:5]#[N:6].O.[NH2:17][NH2:18]>CCO>[NH2:6][C:5]1[NH:18][N:17]=[C:3]([NH:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[C:4]=1[C:7]#[N:8]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 1704453HCID 1704453, compound

Product 1

HCID 4164367HCID 4164367, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Dissolved 2-((methylthio)(phenylamino)methylene)malononitrile (3.2 g) in EtOH (100 mL) and added hydrazine hydrate (1 eq), then heated to reflux until complete by TLC (absence of starting material, 18 hrs). Poured into ice water and filtered to obtain 5-amino-3-(phenylamino)-1H-pyrazole-4-carbonitrile as a yellow powder.

Workup

  1. temperatureheated
  2. temperatureto reflux until complete by TLC (absence of starting material, 18 hrs)
  3. filtrationfiltered

Sources & evidence

ORD record
ord-8e924ff2dc0d49d6875015eca47a8806
Source dataset
uspto-grants-2016_06
Patent number
US09365556B2

Reaction notes

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