Hydrazine hydrate (1:1) → HCID 8812953, compound

HRID 2202624Notes

Reaction equation

HRID 2202624 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9](=[C:12]([C:15]#[N:16])[C:13]#[N:14])SC)=[CH:4][CH:3]=1.O.[NH2:18][NH2:19]>CCO>[NH2:14][C:13]1[NH:19][N:18]=[C:9]([NH:8][C:5]2[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][CH:4]=2)[C:12]=1[C:15]#[N:16]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 13573165HCID 13573165, compound

Product 1

HCID 8812953HCID 8812953, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Dissolved 2-(((4-chlorophenyl)amino)(methylthio)methylene)malononitrile in EtOH (100 mL) and added hydrazine hydrate (1 eq), then heated to reflux until complete by TLC (absence of starting material, 18 hrs). Poured into ice water and filtered to obtain 5-amino-3-((4-chlorophenyl)amino)-1H-pyrazole-4-carbonitrile as a yellow powder.

Workup

  1. temperatureheated
  2. temperatureto reflux until complete by TLC (absence of starting material, 18 hrs)
  3. filtrationfiltered

Sources & evidence

ORD record
ord-c6b6c48c4738463fb2b9877436df2981
Source dataset
uspto-grants-2016_06
Patent number
US09365556B2

Reaction notes

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