Hydrazine hydrate (1:1) → HCID 86698963, compound

HRID 2202626Notes

Reaction equation

HRID 2202626 reaction equation
[CH:1]1([NH:4][C:5](=[C:8]([C:11]#[N:12])[C:9]#[N:10])SC)[CH2:3][CH2:2]1.O.[NH2:14][NH2:15]>CCO>[NH2:10][C:9]1[NH:15][N:14]=[C:5]([NH:4][CH:1]2[CH2:3][CH2:2]2)[C:8]=1[C:11]#[N:12]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 86698962HCID 86698962, compound

Product 1

HCID 86698963HCID 86698963, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

2-((cyclopropylamino)(methylthio)methylene)malononitrile in EtOH (100 mL) and added hydrazine hydrate (1 eq), then heated to reflux until complete by TLC (absence of starting material, 18 hrs). Poured into ice water and filtered to obtain 5-amino-3-(cyclopropylamino)-1H-pyrazole-4-carbonitrile as a yellow powder.

Workup

  1. temperatureheated
  2. temperatureto reflux until complete by TLC (absence of starting material, 18 hrs)
  3. filtrationfiltered

Sources & evidence

ORD record
ord-45a2b354833f42e3bc630aafe345bcf3
Source dataset
uspto-grants-2016_06
Patent number
US09365556B2

Reaction notes

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