Hydrazine hydrate (1:1) → HCID 86698964, compound

HRID 2202628Notes

Reaction equation

HRID 2202628 reaction equation
CS[C:3]([NH:9][C:10]1[CH:15]=[CH:14][C:13]([N+:16]([O-:18])=[O:17])=[CH:12][CH:11]=1)=[C:4]([C:7]#[N:8])[C:5]#[N:6].O.[NH2:20][NH2:21]>CCO>[NH2:6][C:5]1[NH:21][N:20]=[C:3]([NH:9][C:10]2[CH:15]=[CH:14][C:13]([N+:16]([O-:18])=[O:17])=[CH:12][CH:11]=2)[C:4]=1[C:7]#[N:8]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 7718564HCID 7718564, compound

Product 1

HCID 86698964HCID 86698964, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Dissolved 2-((methylthio)((4-nitrophenyl)amino)methylene)malononitrile in EtOH (100 mL) and added hydrazine hydrate (1 eq., 3.64 mL), then heated to reflux until complete by TLC (absence of starting material, 18 hrs). Poured into ice water and filtered to obtain 5-amino-3-((4-nitrophenyl)amino)-1H-pyrazole-4-carbonitrile as a yellow powder.

Workup

  1. temperatureheated
  2. temperatureto reflux until complete by TLC (absence of starting material, 18 hrs)
  3. filtrationfiltered

Sources & evidence

ORD record
ord-3f6b7d91944041b9a5fc5b82de4cedc6
Source dataset
uspto-grants-2016_06
Patent number
US09365556B2

Reaction notes

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