Hydrazine hydrate (1:1) → HCID 86698966, compound

HRID 2202631Notes

Reaction equation

HRID 2202631 reaction equation
[CH:1]1([NH:7][C:8](=[C:11]([C:14]#[N:15])[C:12]#[N:13])SC)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.O.[NH2:17][NH2:18]>CCO>[NH2:13][C:12]1[NH:18][N:17]=[C:8]([NH:7][CH:1]2[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]2)[C:11]=1[C:14]#[N:15]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 1704438HCID 1704438, compound

Product 1

HCID 86698966HCID 86698966, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Dissolved 2-((cyclohexylamino)(methylthio)methylene)malononitrile in EtOH (100 mL) and added hydrazine hydrate (1 eq), then heated to reflux until complete by TLC (absence of starting material, 18 hrs). Poured into ice water and filtered to obtain 5-amino-3-(cyclohexylamino)-1H-pyrazole-4-carbonitrile as a yellow powder.

Workup

  1. temperatureheated
  2. temperatureto reflux until complete by TLC (absence of starting material, 18 hrs)
  3. filtrationfiltered

Sources & evidence

ORD record
ord-2a12fab825304de5851862fdc7c457a1
Source dataset
uspto-grants-2016_06
Patent number
US09365556B2

Reaction notes

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