反应详情

To a solution of 2-iodophenol (1 g, 4.55 mmol) in CH3CN (20 mL) was added K2CO3 (0.93 g, 6.83 mmol) and ethyl 2-bromoacetate (0.835 g, 5.0 mmol). The reaction mixture was stirred at reflux for 2 h, cooled to room temperature, extracted with EtOAc, washed with brine, dried over sodium sulfate and concentrated. The crude product was used in the next step without further purification. (1.1 g, yield 79%) MS (ESI+) e/z: 307.1 [M+1]+.

1. temperatureat reflux for 2 h
2. extractionextracted with EtOAc
3. washwashed with brine
4. dry with materialdried over sodium sulfate
5. concentrationconcentrated
6. customThe crude product was used in the next step without further purification