反应详情

温度

60 °C

To a solution of 0.36 g of 3-furo[2,3-b]pyridin-5-yl-N-methyl-propionamide in 10 ml of THF was added dropwise 2.3 ml of a LiAlH4 (2.3M THF) solution at 0° C. The reaction mixture was slowly heated to 60° C. over 1 h and stirred for another 2 h at 60° C. The reaction was quenched by addition of 1M NaOH solution. The resulting mixture was filtrated over a pad of celite, washed with THF and the filtrate was concentrated in vacuo to yield 0.35 g of (3-furo[2,3-b]pyridin-5-yl-propyl)-methyl-amine as brown oil.

1. customThe reaction was quenched by addition of 1M NaOH solution
2. filtrationThe resulting mixture was filtrated over a pad of celite
3. washwashed with THF
4. concentrationthe filtrate was concentrated in vacuo