反应详情

A mixture of ethyl 3-cyclopropyl-3-oxopropanoate (5.0 g, 32.0 mmol), benzyl alcohol (8.2 mL, 80.0 mmol) and LiOCl (680 mg, 6.4 mmol) in toluene (50 mL) was refluxed for 48 h in flask equipped with a Dean-stark apparatus. The reaction mixture was cooled to room temperature and solvent was removed under reduced pressure to provide compound D20-1 (5.2 g, crude) as a brown oil.

1. temperaturewas refluxed for 48 h in flask
2. customequipped with a Dean-stark apparatus
3. customsolvent was removed under reduced pressure
4. customto provide compound D20-1 (5.2 g, crude) as a brown oil