Benzyl Alcohol → Benzyl 3-cyclopropyl-3-oxopropanoate

HRID 2202722ノート

反応式

HRID 2202722 の反応式
[CH:1]1([C:4](=[O:11])[CH2:5][C:6]([O:8][CH2:9][CH3:10])=[O:7])[CH2:3][CH2:2]1.C(O)[C:13]1[CH:18]=[CH:17]C=[CH:15][CH:14]=1.O(Cl)[Li]>C1(C)C=CC=CC=1>[CH:1]1([C:4](=[O:11])[CH2:5][C:6]([O:8][CH2:9][C:10]2[CH:17]=[CH:18][CH:13]=[CH:14][CH:15]=2)=[O:7])[CH2:3][CH2:2]1

参加物

5

反応物 3

HCID 244Benzyl AlcoholHCID 262979Ethyl 3-cyclopropyl-3-oxopropanoateHCID 178506945lithium hypochlorite

生成物 1

HCID 10680329Benzyl 3-cyclopropyl-3-oxopropanoate

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

A mixture of ethyl 3-cyclopropyl-3-oxopropanoate (5.0 g, 32.0 mmol), benzyl alcohol (8.2 mL, 80.0 mmol) and LiOCl (680 mg, 6.4 mmol) in toluene (50 mL) was refluxed for 48 h in flask equipped with a Dean-stark apparatus. The reaction mixture was cooled to room temperature and solvent was removed under reduced pressure to provide compound D20-1 (5.2 g, crude) as a brown oil.

後処理

  1. temperaturewas refluxed for 48 h in flask
  2. customequipped with a Dean-stark apparatus
  3. customsolvent was removed under reduced pressure
  4. customto provide compound D20-1 (5.2 g, crude) as a brown oil

出典と根拠

ORDレコード
ord-ff4be83699c34bc1b61ad53e93bbe099
出典データセット
uspto-grants-2016_06
特許番号
US09365522B2

反応ノート

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